Tag Archives: antiphospholipid antibody syndrome

3rd Place EMage Winner-Bruising after a Viral Illness

Laura A Scieszka, MD  and Tricia Swan, MD

University of Florida College of Medicine, Department of Pediatric Emergency Medicine, Gainesville, Florida

Case

A 6-year-old, unvaccinated, female presented to our pediatric emergency department with 2 days of unexplained bruising, left ankle pain and swelling, and intermittent gingival bleeding following a recent illness of vomiting and non-bloody diarrhea which had resolved 2 days prior to presentation.  Her associated symptoms included mild periumbilical abdominal pain and reported abdominal distension. Her parent denied any recent trauma, travel, medication use, ingestions, fevers, or jaundice.  The patient had no contributory family history. Physical exam findings were significant for dried blood in her mouth, around her teeth, and on her lips; tenderness to palpation of the dorsal aspect of her left ankle with mild swelling; and multiple large ecchymosis to her bilateral lower extremities, right flank and right shoulder. Her workup included a left ankle CT, abdominal ultrasound with Doppler, hepatitis panel, and Epstein Barr Virus, all of which were negative. Her remarkable lab results were prolonged aPTT >150, prothrombin 46.7, and INR 3.8. During her inpatient stay, she had decreased activity of factors 2 (thrombin), 7, 8, and 9. Mixing studies did not correct the patient’s bleeding time, which indicated the presence of an anticoagulant. Her diluted Russell viper venom (DRVV) test was positive, which is consistent with lupus anticoagulant (LA) antiphospholipid antibody syndrome (APS). read more